Preparation and In Vivo Antinociceptive Behavior of Four New 2‐Amino‐6‐trifuromethoxybenzothiazole Carboxylic Acid Derivatives | Zendy

Wu Xianglong | Zendy; Wang Qingchuan | Zendy; Zhang Fei | Zendy; Liu Hao | Zendy; Lu Tingli | Zendy; Zhang Qichun | Zendy

Premium

Preparation and In Vivo Antinociceptive Behavior of Four New 2‐Amino‐6‐trifuromethoxybenzothiazole Carboxylic Acid Derivatives

Author(s) -

Wu Xianglong,

Wang Qingchuan,

Zhang Fei,

Liu Hao,

Lu Tingli,

Zhang Qichun

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201902921

Subject(s) - benzothiazole , riluzole , chemistry , nociception , in vivo , hot plate test , pharmacology , acetic acid , hot plate , stereochemistry , medicinal chemistry , organic chemistry , glutamate receptor , biochemistry , medicine , receptor , materials science , microbiology and biotechnology , composite material , biology

Four novel N ‐substituted riluzole derivatives ( 4 a ‐ 4 d ) have been prepared and characterized. Their antinociceptive activities have been carefully investigated by hot‐plate test and writhing test. Our results indicated that at dose of 18 mg kg −1 , 2‐( N ‐propionic acid)‐6‐trifluoromethoxy‐benzothiazole ( 4 a ), 2‐( N ‐butanoic acid)‐6‐trifluoromethoxy‐benzothiazole ( 4 b ) and 2‐( N ‐n‐caproic acid)‐6‐trifluoromethoxy‐benzothiazole ( 4 c ) significantly increased the nociceptive response latency under hot plate test while chemical nociception induced by intraperitoneal acetic acid was significantly inhibited by 4 a and 2‐( N ‐proline)‐6‐trifluoromethoxy‐benzothiazole ( 4 d ) at same dosage. Our research clearly indicates that N ‐substituted Riluzole derivatives could be new alternative candidates as potential antinociceptive medicines.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research