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Preparation and In Vivo Antinociceptive Behavior of Four New 2‐Amino‐6‐trifuromethoxybenzothiazole Carboxylic Acid Derivatives
Author(s) -
Wu Xianglong,
Wang Qingchuan,
Zhang Fei,
Liu Hao,
Lu Tingli,
Zhang Qichun
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902921
Subject(s) - benzothiazole , riluzole , chemistry , nociception , in vivo , hot plate test , pharmacology , acetic acid , hot plate , stereochemistry , medicinal chemistry , organic chemistry , glutamate receptor , biochemistry , medicine , receptor , materials science , microbiology and biotechnology , composite material , biology
Four novel N ‐substituted riluzole derivatives ( 4 a ‐ 4 d ) have been prepared and characterized. Their antinociceptive activities have been carefully investigated by hot‐plate test and writhing test. Our results indicated that at dose of 18 mg kg −1 , 2‐( N ‐propionic acid)‐6‐trifluoromethoxy‐benzothiazole ( 4 a ), 2‐( N ‐butanoic acid)‐6‐trifluoromethoxy‐benzothiazole ( 4 b ) and 2‐( N ‐n‐caproic acid)‐6‐trifluoromethoxy‐benzothiazole ( 4 c ) significantly increased the nociceptive response latency under hot plate test while chemical nociception induced by intraperitoneal acetic acid was significantly inhibited by 4 a and 2‐( N ‐proline)‐6‐trifluoromethoxy‐benzothiazole ( 4 d ) at same dosage. Our research clearly indicates that N ‐substituted Riluzole derivatives could be new alternative candidates as potential antinociceptive medicines.