Premium
Dopamine Loaded SiO 2 Coated Fe 3 O 4 Magnetic Nanoparticles: A New Anticancer Agent in pH‐Dependent Drug Delivery
Author(s) -
Dey Chaitali,
Das Arpita,
Goswami Madhuri Mandal
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902909
Subject(s) - transmission electron microscopy , high resolution transmission electron microscopy , selected area diffraction , fourier transform infrared spectroscopy , materials science , magnetic nanoparticles , nanoparticle , iron oxide nanoparticles , nanotechnology , nuclear chemistry , drug delivery , analytical chemistry (journal) , chemical engineering , chemistry , chromatography , engineering
Abstract In this present study, we have shown dopamine acts as very good agent in killing cancer cells with very high rate. We have used silica coated iron oxide magnetic particles as dopamine drug delivery agent. We have synthesized iron oxide (Fe 3 O 4 ) magnetic nanoparticles (MNPs), and coated it with silicon dioxide (SiO 2 ), then loaded it with dopamine (DA) which has been used here as anticancer drug. Here a significant improvement was found in case of drug release under acidic pH than normal blood pH. The MNPs are characterized using X‐ray diffraction (XRD), Energy Dispersive Analysis of X‐rays (EDAX), Fourier transform infrared (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), High Resolution Transmission Electron Microscopy (HRTEM), Selected Area Electron Diffraction (SAED) and vibrating sample magnetometer (VSM) to confirm its structural, morphological and magnetic properties. Particles after characterization were involved in investigation of DA drug release by altering pH for better treatment of cancer. The results are very important and promising.