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One‐Pot Three‐Component Synthesis of 3‐Aminoalkyl Indoles Catalyzed by Molecular Iodine
Author(s) -
Depa Navaneetha,
Erothu Harikrishna
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902832
Subject(s) - iodine , catalysis , alkyl , chemistry , component (thermodynamics) , reaction conditions , combinatorial chemistry , one pot synthesis , coupling reaction , organic chemistry , polymer chemistry , physics , thermodynamics
A facile one‐pot three‐component coupling (3CC) of indoles, aldehydes, and N ‐alkyl anilines has been attained using a catalytic quantity of molecular iodine under neutral conditions to afford 3‐aminoalkyl indoles at room temperature. The salient features of this method are the mild reaction conditions, the operational simplicity of the method, outstanding yields in moderately at short reaction times and low cost of the catalyst.