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Recent Advances and Prospects in the Tishchenko Reaction
Author(s) -
Dhanya Raju,
Shilpa Thomas,
Saranya Salim,
Anilkumar Gopinathan
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902776
Subject(s) - aldehyde , chemistry , catalysis , natural product , combinatorial chemistry , organic chemistry
Tishchenko reaction is the dimerization of two molecules of an aldehyde to produce symmetrical esters. These esters find wide applications in many reactions in organic synthesis. A variant of this reaction, the Evans‐Tishchenko reaction, catalyzed by SmI 2 affords 1,3‐ anti ‐diol monoesters. This chemistry has found wide applications in natural product synthesis as it offers a mild and efficient methodology for the formation of 1,3‐diols stereoselectively. In this review, we mainly focus on recent advancements in the transition metal catalyzed and lanthanide‐actinide catalyzed Tishchenko reactions and their applications in organic synthesis covering literature from 2014 to 2019.