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Two‐Step Preparation of Diverse 3‐Amidofurans from Chitin
Author(s) -
Pham Thuy Trang,
Lindsay Ashley C.,
Kim ShiWei,
Persello Laly,
Chen Xi,
Yan Ning,
Sperry Jonathan
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902765
Subject(s) - chitin , substituent , furan , chemical space , combinatorial chemistry , chemistry , nanotechnology , organic chemistry , materials science , chitosan , biochemistry , drug discovery
The synthesis of 3‐amidofurans is laborious due to the difficulty installing a nitrogen substituent at the C3 position of the furan heterocycle. 3‐Acetamido‐5‐acetylfuran (3A5AF), readily available from chitin, is a versatile biorenewable platform that can be converted into a range of functionally rich 3‐amidofurans, streamlining access to this underexplored heteroaromatic chemical space.