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Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter
Author(s) -
Galstyan Armen S.,
Ghochikyan Tariel V.,
Samvelyan Melanya A.,
Frangyan Vardges R.,
Sarfraz Muhammad
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902761
Subject(s) - biological activity , antifungal , candida albicans , thiol , chemistry , triazole , sulfur , structure–activity relationship , 1,2,4 triazole , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , biology , in vitro , microbiology and biotechnology
Screening in a series of 1,2,4‐triazole derivatives has revealed an antinematode property in relation to positive nematodes. A certain relationship has been established between the structure and biological activity of the proposed compounds. It has been experimentally proved, that if the sulfur is present in molecules in the thionic form only, it leads to an increase in the viability of nematodes by 3–4%, and if compounds contain only the thiol form, it decreases the viability of nematodes by 20–40% depending on the concentration of the compounds used. It was also found that bis‐triazoles containing only the thiol form demonstrated antifungal activity, inhibiting the growth of C. albicans by 35–40%.