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Reactions of 1‐(3,3‐Diethoxypropyl)urea with Phenols: Synthesis of 1,6‐Disubstituted Tetrahydropyrimidine‐2(1H)‐ones
Author(s) -
Smolobochkin Andrey V.,
Gazizov Almir S.,
Voronina Julia K.,
Strelnik Anna G.,
Rizbayeva Tanzilya S.,
Burilov Alexander R.,
Pudovik Michail A.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902754
Subject(s) - phenols , urea , reagent , catalysis , chemistry , alkyl , organic chemistry , combinatorial chemistry , organic synthesis
Ureas containing alkyl aromatic fragments are an important class of organic compounds due to their high pharmacological activity. However, at the moment there is no common and simple method for the synthesis of these classes of compounds. Therefore, in the present work we propose a new approach to the synthesis of 1,6‐disubstituted tetrahydropyrimidine‐2(1H)‐ones via the acid‐catalyzed reaction of (3,3‐diethoxypropyl) urea with various phenols. The proposed approach allows to obtain target compounds in one‐pot manner and without the use of expensive reagents and catalysts.