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Cu–Catalyzed C5 Nitration of Indolines under Mild Conditions
Author(s) -
Gao Shanshan,
Ma Yaorui,
Tang Hao,
Luo Junfei,
Wang Kuan
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902743
Subject(s) - nitration , regioselectivity , catalysis , chemistry , nitro , nitrite , medicinal chemistry , organic chemistry , combinatorial chemistry , nitrate , alkyl
A Cu‐catalyzed remote C—H nitration of indolines by the use of cheap and green tert ‐butyl nitrite as an organo‐nitro surrogate has been reported. The reactions were performed at room temperature under air conditions without any other oxidant. The method exhibited high regioselective, direct nitration of indolines at the C5 position.