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N‐Arylation of Fluoroalkylamine and Trifluoroacetamide through Cu–Catalysis
Author(s) -
Xin Jiaqi,
Leng Faqiang
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902689
Subject(s) - aryl , chemistry , catalysis , copper , functional group , combinatorial chemistry , organic chemistry , alkyl , polymer
Copper mediated coupling of fluoro‐alkylamines/trifluoroacetamide and aryl‐boronic acids have been developed. N‐arylation of di/trifluoroethylamine was achieved by a Cu(OAc) 2 /Py system with AgNO 3 as an additive, while the N‐arylation of trifluoroacetamide was described with Cu(OAc) 2 /TEA system. These protocols could tolerate a variety of functional groups of hetero/aryl‐boronic acids, furnishing the corresponding products with moderate to good yields under mild and simple conditions.