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Polyethylene‐Glycol‐ (PEG‐400) Mediated Environmentally Benign Protocol for the Synthesis of Pyrrolo[1,2‐a]quinoxalines from Benzyl Amines at Room Temperature
Author(s) -
Patil Bhausaheb N.,
Lade Jatin J.,
Pardeshi Sachin D.,
Patil Prashant,
Chaskar Atul C.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902656
Subject(s) - benzylamine , polyethylene glycol , peg ratio , chemistry , yield (engineering) , peg 400 , pyrrole , combinatorial chemistry , solvent , amine gas treating , organic chemistry , condensation , functional group , materials science , physics , polymer , finance , economics , metallurgy , thermodynamics
Abstract A metal‐free, adorable, cascade protocol for the synthesis of pyrrolo[1,2‐ a ]quinoxalines at room temperature using benzylamine derivatives and 1‐(2‐aminoaryl)pyrrole has been performed. This synthetic protocol involves oxidation of benzylamine derivatives into respective aldehydes followed by condensation with 1‐(2‐aminoaryl)pyrrole in PEG‐400 as a green and reusable solvent using K 2 S 2 O 8 as an oxidant. The transition metal free as well as ligand free synthesis along with broad substrate scope, wide functional group tolerance and good to excellent yield of products makes it environmentally and economically viable.