Premium
A Metal‐free Approach for the Synthesis of Privileged 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐one Derivatives over a Heterogeneous Catalyst
Author(s) -
Mathavan Sivagami,
Durai Raj Ajith Kumar,
Yamajala Rajesh B. R. D.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902638
Subject(s) - catalysis , reusability , substrate (aquarium) , combinatorial chemistry , chemistry , heterogeneous catalysis , scope (computer science) , reactivity (psychology) , organic chemistry , computer science , medicine , alternative medicine , software , pathology , programming language , oceanography , geology
The use of sustainable and efficient heterogeneous catalyst system TsOH‐SiO 2 shows unprecedented catalytic efficiency in the synthesis of biologically active 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐one derivatives from 2‐aminopyridine and β‐oxo esters. The protocol provides advantages such as faster reactivity, high catalytic activities without any additives, high yields, no toxic/corrosive byproducts, broad substrate scope, reusability of the catalyst under solvent‐free conditions and scalable to gram scale, thus having economical and ecological advantages.