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Acetoxylation and Halogenation of 2‐Arylbenzoxazinones via Palladium‐Catalyzed C(sp 2 )‐H Bond Oxidation
Author(s) -
Vu Huu Manh,
Chen FeiWu,
Li XuQin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902611
Subject(s) - halogenation , selectivity , palladium , catalysis , chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry
Methods of selective synthesis of C−H acetoxylated and halogenated 2‐arylbenzoxazinones were developed. The reactions went smoothly under the benign conditions and gave the corresponding products with high selectivity. The methods are compatible to the 2‐arylbenzoxazinones with either electron‐withdrawing or electron‐donating groups. Additionally, this transformation can also be scaled up to the gram level. This strategy allows for direct preparation of products, thus providing a good complement to previous C−H oxidations and expanding the field of benzoxazinone as Directing Groups.