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2,4‐Diphenyl‐1,2‐dihydroquinazoline Derivatives: Synthesis, Anticancer Activity and Docking Studies
Author(s) -
Gudimella Krishna Kanthi,
Bonige Kishore Babu,
Gundla Rambabu,
Katari Naresh Kumar,
Yamajala Bhaskar,
Battula Venkateswara Rao
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902609
Subject(s) - chemistry , ammonium acetate , docking (animal) , combinatorial chemistry , stereochemistry , benzylamine , cancer cell lines , hydrazone , medicinal chemistry , organic chemistry , cancer cell , medicine , high performance liquid chromatography , nursing , cancer
A straightforward, rapid and efficient one‐pot method was developed for the synthesis of 2,4 ‐diphenyl‐1,2 dihydroquinazoline and their analogues. The reactions were performed with different type of benzylamine and 2‐bromo benzophenone using ammonium acetate and characterized by 1 H NMR, 13 C NMR and Mass spectroscopic techniques. All the compounds were tested for MDA‐MB‐231, A549 and DU‐145 type of human cancer cell lines. Among the synthesized compounds, 4 j ( 4‐phenyl‐2‐(3,4,5‐trimethoxyphenyl)‐1,2‐dihydroquinazoline) and 4 e ( 2‐(3,4‐dichlorophenyl)‐4‐phenyl‐1,2‐dihydroquinazoline) molecules were found to possess good anticancer activity. The binding nature of these molecules was explored through docking studies.