Sulfobetaine  N ‐Chloramines: Chemical Synthesis and Antibacterial Application | Zendy

Li Lingdong | Zendy; Wang Hande | Zendy; Jin Yanan | Zendy; Wang Peiqi | Zendy; Jia Dongxue | Zendy

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Sulfobetaine N ‐Chloramines: Chemical Synthesis and Antibacterial Application

Author(s) -

Li Lingdong,

Wang Hande,

Jin Yanan,

Wang Peiqi,

Jia Dongxue

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201902555

Subject(s) - chloramine , chemistry , linker , antibacterial activity , covalent bond , ionic bonding , combinatorial chemistry , organic chemistry , chlorine , bacteria , ion , biology , computer science , genetics , operating system

A series of sulfobetaine N ‐chloramines, covalently combining an N ‐chloramine unit and a sulfobetaine unit with varied intercharge linkers, were chemically synthesized. Preliminary antibacterial tests showed that the antibacterial activity decreased as the methylene linker increases from ‐(CH 2 ) 2 ‐ to ‐(CH 2 ) 8 ‐ except the linker of ‐(CH 2 ) 6 ‐, which exerted remarkable bactericidal efficacy unusually. In addition, the analogue with the linker of ‐(CH 2 ) 10 ‐ displayed the highest bactericidal efficacy among all synthetic N ‐chloramines, probably due to its neutral zwitterionic characteristic on structure. Our research provided highly efficacious antibacterial agents together with the vital references to design novel ionic N ‐chloramine biocides.

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