Metal‐free, Visible‐Light‐Induced Radical Trifluoromethylation/Cyclization of N‐benzamides with CF 3 SO 2 Na to Synthesize CF 3 ‐Containing Isoquinoline‐1,3‐diones | Zendy

Wang Shaowei | Zendy; Dai Peng | Zendy; Yan Zhichao | Zendy; Wang Youjia | Zendy; Shao Jiaxuan | Zendy; Wu Yanhui | Zendy; Deng Chao | Zendy; Zhang Weihua | Zendy

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Metal‐free, Visible‐Light‐Induced Radical Trifluoromethylation/Cyclization of N‐benzamides with CF 3 SO 2 Na to Synthesize CF 3 ‐Containing Isoquinoline‐1,3‐diones

Author(s) -

Wang Shaowei,

Dai Peng,

Yan Zhichao,

Wang Youjia,

Shao Jiaxuan,

Wu Yanhui,

Deng Chao,

Zhang Weihua

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201902545

Subject(s) - isoquinoline , trifluoromethylation , chemistry , combinatorial chemistry , antifungal , medicinal chemistry , organic chemistry , trifluoromethyl , medicine , alkyl , dermatology

A novel visible‐light‐induced radical cascade trifluoromethylation/cyclization of N‐benzamides with CF 3 SO 2 Na has been achieved. This protocol provides an efficient strategy for the synthesis of CF 3 ‐containing isoquinoline‐1,3‐diones under mild reaction conditions. The reaction features metal‐free, air oxidation, CF 3 SO 2 Na as CF 3 source, additives free and operational simplicity. Moreover, the representative products displayed significant potencial antifungal activities in vitro.

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