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BF 3 ⋅Et 2 O‐Promoted Aerobic Bromination of Heteroarenes with LiBr as the Bromination Sources
Author(s) -
Shao Huibin,
Wang Xiaopei,
Wang Yanyan,
Yue Yuanyuan,
Wang Ke,
Tang Qinghu,
Zhuo Kelei,
Liu Jianming
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902492
Subject(s) - halogenation , chemistry , reaction conditions , bromide , aromaticity , functional group , medicinal chemistry , organic chemistry , catalysis , molecule , polymer
Aromatic bromination of heteroarenes has been accomplished by using readily available LiBr with the aid of BF 3 ⋅Et 2 O under mild aerobic conditions. The broad substrates scope of the reaction is compatible with the optimized condition, and excellent functional‐group is well tolerated in this transformation. The gram‐scale preparation of aromatic bromide exhibits with good reaction efficiency. Meanwhile, the dibromination of heteroarene delivers the polybromo‐aromatic compounds in good yields.