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An Easy Access to 4‐Trifluoromethylated 7‐(4‐Substitued‐1 H ‐1,2,3‐Triazol‐1‐yl)Pyrimido[1,2‐ b ]Pyridazin‐2‐One Systems
Author(s) -
Kawtharani Ranin,
Cherry Khalil,
Elmasri Mirvat,
Abarbri Mohamed
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902375
Subject(s) - chemistry , trifluoromethyl , cycloaddition , azide , medicinal chemistry , triazole , stereochemistry , 1,2,3 triazole , copper , combinatorial chemistry , catalysis , organic chemistry , alkyl
Efficient synthesis of 7‐(1 H ‐1,2,3‐triazol‐1‐yl)‐4‐trifluoromethyl‐2 H ‐pyrimido[1,2‐ b ]pyridazin‐2‐ones from 7‐chloro‐4‐trifluoromethylpyrimido[1,2‐ b ]pyridazin‐2‐one by a consecutive SN Ar reaction with azide, followed by copper‐catalyzed [3+2] cycloaddition is described.