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An Overview of Recent Advances in the Applications of Click Chemistry in the Synthesis of Bioconjugates with Anticancer Activities
Author(s) -
Mashayekh Koroush,
Shiri Pezhman
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902362
Subject(s) - click chemistry , cycloaddition , chemistry , combinatorial chemistry , cancer therapy , nanotechnology , organic chemistry , cancer , medicine , catalysis , materials science
The click chemistry is one of the most powerful C−N bond forming‐reactions towards five‐membered heterocycles. The copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) has widely used in the discovery of anti‐cancer drugs and many articles have been published in this field. This review article aims to review general mechanism aspects and the recent advances (2016–2019) of click chemistry for cancer therapy.