A Serendipitous Synthesis: SiO 2 ‐HNO 3  Mediated Oxidative Aromatization and Regioselective Nitration of 1,3,5‐Trisubstituted‐4,5‐Dihydro‐1 H ‐Pyrazoles | Zendy

Bhatia Rimpy | Zendy; Kadyan Kulbir | Zendy; Duhan Meenakshi | Zendy; Devi Meena | Zendy; Singh Rahul | Zendy; Kamboj Ramesh C. | Zendy; Kumar Parvin | Zendy

Premium

A Serendipitous Synthesis: SiO 2 ‐HNO 3 Mediated Oxidative Aromatization and Regioselective Nitration of 1,3,5‐Trisubstituted‐4,5‐Dihydro‐1 H ‐Pyrazoles

Author(s) -

Bhatia Rimpy,

Kadyan Kulbir,

Duhan Meenakshi,

Devi Meena,

Singh Rahul,

Kamboj Ramesh C.,

Kumar Parvin

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201902285

Subject(s) - regioselectivity , nitration , oxidizing agent , aromatization , chemistry , oxidative phosphorylation , catalysis , combinatorial chemistry , organic chemistry , biochemistry

Research often leads to unprecedented results that open the gates for new methodologies. We report herein the oxidative aromatization and serendipitous regioselective nitration of 1,3,5‐trisubstituted‐4,5‐dihydro‐1 H ‐pyrazoles under mild reaction conditions using SiO 2 ‐HNO 3 as an oxidizing agent to afford 1,3,5‐trisubstituted pyrazoles with high regioselectivity. Here SiO 2 ‐HNO 3 acts as a nitrating agent along with oxidizing property. SiO 2 ‐HNO 3 is cheap, easy to prepare, eco‐friendly and practically applicable catalyst.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research