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A Serendipitous Synthesis: SiO 2 ‐HNO 3 Mediated Oxidative Aromatization and Regioselective Nitration of 1,3,5‐Trisubstituted‐4,5‐Dihydro‐1 H ‐Pyrazoles
Author(s) -
Bhatia Rimpy,
Kadyan Kulbir,
Duhan Meenakshi,
Devi Meena,
Singh Rahul,
Kamboj Ramesh C.,
Kumar Parvin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902285
Subject(s) - regioselectivity , nitration , oxidizing agent , aromatization , chemistry , oxidative phosphorylation , catalysis , combinatorial chemistry , organic chemistry , biochemistry
Research often leads to unprecedented results that open the gates for new methodologies. We report herein the oxidative aromatization and serendipitous regioselective nitration of 1,3,5‐trisubstituted‐4,5‐dihydro‐1 H ‐pyrazoles under mild reaction conditions using SiO 2 ‐HNO 3 as an oxidizing agent to afford 1,3,5‐trisubstituted pyrazoles with high regioselectivity. Here SiO 2 ‐HNO 3 acts as a nitrating agent along with oxidizing property. SiO 2 ‐HNO 3 is cheap, easy to prepare, eco‐friendly and practically applicable catalyst.