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l‐ Glutamine Supported on Core–Shell Silica Iron Oxide Nanoparticles: A Highly Efficient Organocatalyst for Synthesis of Spirooxoindoles
Author(s) -
Dutta Arup,
Rahman Noimur,
Khongriah Welfareson,
grum Ridaphun,
Joshi Santa R.,
gkhlaw Rishanlang
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902279
Subject(s) - catalysis , thermogravimetric analysis , fourier transform infrared spectroscopy , scanning electron microscope , nuclear chemistry , inductively coupled plasma , nanoparticle , nanomaterials , chemistry , spectroscopy , materials science , transmission electron microscopy , chemical engineering , analytical chemistry (journal) , nanotechnology , organic chemistry , composite material , plasma , physics , quantum mechanics , engineering
A novel, eco‐friendly super paramagnetic organo‐nano catalyst was fabricated by encapsulating ferrite@silica (Fe 3 O 4 @SiO 2 ) nanoparticles with l ‐Glutamine. The prepared catalyst was characterized by various analytical techniques viz ., fourier transform infrared spectroscopy (FT‐IR), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), Scanning electron microscopy (SEM), Energy Dispersive X‐ray analysis (EDX), powder X‐ray diffraction technique (XRD), vibrating sample magnetometer spectroscopy (VSM), Inductively coupled plasma optical emission spectroscopy (ICP‐OES) and its catalytic activity was investigated for the synthesis of spirooxindole derivatives. Utilizing the ferromagnetic nature of Fe 3 O 4 nanoparticles, the prepared catalyst could be easily retrieved from the reaction mixture after completion of the reaction by using an external magnet. The catalyst was reused up to six runs with remarkable catalytic activity. The main advantages of this synthetic approach lie in its operational simplicity, cost effectiveness, higher yields, easy catalyst recyclability and reusability, eco‐friendly procedures and shorter reaction times. Also, the antimicrobial assay of the synthesized spirooxoindoles was evaluated against three bacterial isolates and one fungal isolate, and the results showed profound antimicrobial activities.