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A Highly Enantioselective and Efficient Synthesis of New Pyrimidine‐Fused Spiro[indoline‐3,4′‐pyran]s Promoted by a Novel Chiral Ionic Liquid
Author(s) -
Ahmadkhani Amin,
RadMoghadam Kurosh,
Roudsari Saeedeh Toorchi
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902231
Subject(s) - ionic liquid , enantioselective synthesis , pyrimidine , chemistry , pyran , ionic bonding , medicinal chemistry , organic chemistry , stereochemistry , catalysis , ion
A nearly neutral but protic chiral ionic liquid was prepared via neutralization of (1 S)‐(+)‐camphor‐10‐sulfonic acid with N,N ‐dimethyl‐n‐octylamine. The structure of this room temperature ionic liquid was confirmed by NMR spectroscopy. It was proved to be an efficient mild promoter for the synthesis of some novel spiro‐oxindoles. The ionic liquid has shown a high asymmetric induction potential, as the spiro‐oxindoles were obtained in high optical purities. All the synthesized spiro‐compounds are new.