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Ultrasonic Cavitation Facilitates Rapid Synthesis of Trisubstituted Pyrazole Scaffolds through Michael Addition/Domino Cyclization
Author(s) -
Kannan Damodharan,
Naveen Shivalingegowda,
Jagadeesan Ganapathy,
Lokanath Nerattur Krishnappagowda,
Thennarasu Sathiah
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902126
Subject(s) - pyrazole , domino , michael reaction , aryl , ultrasonic sensor , combinatorial chemistry , chemistry , cavitation , cascade reaction , organic chemistry , catalysis , medicine , alkyl , physics , mechanics , radiology
Abstract A series of aryl/indolyl substituted 4, 5‐dihydro‐1H‐pyrazole derivatives were synthesized via a domino method based on Michael addition mediated cyclization of appropriate chalcones. The chalcones were prepared by Witting reaction in which substituted aromatic aldehydes were treated with stable ylides under eco‐friendly ultrasonic cavitation. The pyrazole scaffolds were obtained in excellent yields within a short span of time.