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A Metal‐Free, Organo Lewis Acid Catalyzed Synthesis of Highly Substituted Oxazoles
Author(s) -
Kumaraswamy Gullapalli,
Gangadhar Maram
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902069
Subject(s) - oxazole , lewis acids and bases , chemistry , catalysis , alkyl , aryl , lewis acid catalysis , combinatorial chemistry , organic chemistry
Organoboron Lewis acid‐catalyzed synthesis of oxazole derivatives from α‐diazocarbonyl ketones/esters and aryl/alkyl nitriles has been accomplished. This protocol is compatible with an array of functional groups and results in various scaffolds of oxazole derivatives in good to high yields. Through this process, substitution variation can be achieved easily. Also, the tentative mechanism for the product formation was proposed.