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A ligand and Palladium‐free Avenue for Cyanation of Aryl Halides: The Art of Samarium Powder in C–C Coupling Reaction
Author(s) -
Moghaddam Firouz Matloubi,
Pourkaveh Raheleh,
Gholamtajari Milad,
Karimi Ashkan
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902018
Subject(s) - cyanation , palladium , aryl , samarium , halide , chemistry , ligand (biochemistry) , aryl halide , medicinal chemistry , coupling reaction , catalysis , combinatorial chemistry , organic chemistry , biochemistry , alkyl , receptor
This is the first study of samarium powder catalyzed cyanation reaction of aryl halides, bearing electron‐withdrawing and electron‐releasing substituents, in the presence of NaCN to afford corresponding benzonitriles in high yields. This protocol takes the advantage of being done in the absence of additive, ligand and precious transition metals such as palladium.