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An NBD‐Based Mitochondrial Targeting Ratiometric Fluorescent Probe for Hydrogen Sulfide Detection
Author(s) -
Jia Xu,
Li Wei,
Guo Zihan,
Guo Zhenbo,
Li Yin,
Zhang Pingzhu,
Wei Chao,
Li Xiaoliu
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901991
Subject(s) - hydrogen sulfide , fluorescence , chemistry , hela , endogeny , triphenylphosphine , selectivity , molecule , small molecule , biophysics , photochemistry , biochemistry , biology , organic chemistry , in vitro , optics , physics , catalysis , sulfur
Hydrogen sulfide (H 2 S) is an important endogenous gaseous signaling molecule with multiple biological functions. In this study, an NBD‐based ratiometric fluorescent probe ( MR‐1 ) was successfully designed and synthesized for selectively detection H 2 S. The probe exhibits high selectivity and fast emission intensity ratio changes in response to H 2 S in solution. The modification of triphenylphosphine in the probe enables it to be used for the imaging mitochondrial H 2 S in living HeLa cells.
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