Premium
Dppf‐Ligated Palladium Complex as an Efficient Catalyst for the Synthesis of Biaryl Ketones Using Co 2 (CO) 8 as a C1 Source with High TON and TOF
Author(s) -
Gaikwad Vinayak V.,
Mane Pravin A.,
Dey Sandip,
Bhanage Bhalchandra M.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901930
Subject(s) - ton , catalysis , palladium , yield (engineering) , chemistry , substrate (aquarium) , combinatorial chemistry , single crystal , medicinal chemistry , organic chemistry , materials science , crystallography , oceanography , fishery , metallurgy , biology , geology
In this reports, we have synthesized and characterized the palladium catalyst [Pd 2 (dppf) 2 (SC 12 H 8 S)] 2 (OTf) 4 which is successfully applied for Carbonylative Suzuki‐Miyaura cross‐coupling reaction. Synthesized catalyst was characterized by various analytical techniques such as 1 H NMR, 31 P NMR, CHNS, and single crystal X‐ray diffraction. The use of Co 2 (CO) 8 as a C1 source instead of gaseous CO is an additional advantage of the developed protocol. The current protocol showing excellent catalytic activity at ppm level of “Pd” concentration to provided high TON and TON. TON could be achieved up to 10 4 and TOF up to 10 3 . The protocol could tolerate a variety of functional groups and provided wide substrate scope including Heteroaryl ketones. The practical applicability of the proposed protocol up to gram level with marginal loss of the yield of the product. Remarkably, we have synthesized (4‐methoxyphenyl) (3,4,5‐trimethoxyphenyl)methanone and oxybenzone which is pharmaceutically active drug molecules under co‐catalyst, and additive free condition. .