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Synthesis, Antimicrobial Screening and In Silico Appraisal of Iminocarbazole Derivatives
Author(s) -
Jejurkar Valmik P.,
Mali Suraj N.,
Kshatriya Rajpratap,
Chaudhari Hemchandra K.,
Saha Satyajit
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901890
Subject(s) - klebsiella pneumoniae , in silico , antimicrobial , candida albicans , in vitro , staphylococcus aureus , chemistry , ligand (biochemistry) , microbiology and biotechnology , combinatorial chemistry , antifungal , stereochemistry , biology , computational biology , biochemistry , bacteria , receptor , escherichia coli , genetics , gene
Molecular hybridization, a unique concept for rational drug designing, has been manifested in the design and synthesis of novel iminocarbazole derivatives. All the prepared molecules were tested for their in‐vitro antimicrobial potential against Staphylococcus aureus ATCC 6538 (Gram‐positive), Klebsiella pneumoniae ATCC 4352 (Gram‐negative) and Candida albicans ATCC 10231 (Fungi). All compounds showed moderate to potent antimicrobial activity (1.4 μg/mL‐125 μg/mL). The molecular modeling studies were accomplished to understand the possible ligand‐receptor intermolecular interactions together with the in‐silico ADMET predictions for all newly synthesized iminocarbazoles.