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Fabrication of a Zn(II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity
Author(s) -
Dutta Basudeb,
Pal Kunal,
Jana Kuladip,
Sinha Chittaranjan,
Mir Mohammad Hedayetullah
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901887
Subject(s) - pillar , bilayer , antimicrobial , escherichia coli , antibacterial activity , metal , staphylococcus aureus , metal organic framework , chemistry , crystallography , fabrication , materials science , nanotechnology , nuclear chemistry , bacteria , organic chemistry , membrane , biochemistry , biology , genetics , structural engineering , adsorption , engineering , gene , medicine , alternative medicine , pathology
A Zn(II)‐based two‐dimensional (2D) pillar bilayer metal‐organic framework (MOF) [{Zn(aip)(4,4′‐bpy) 0.5 (MeOH)}⋅(H 2 O)] n ( 1 ), (H 2 aip=5‐aminoisophthalic acid and 4,4′‐bpy=4, 4′‐bipyridine) has been designed and structurally characterized by single crystal X‐ray diffraction (SCXRD) technique. Compound 1 exhibits considerable antibacterial activity upon Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), for which IC 50 values have been obtained as 86.26±1.2 μg/ml and 95.96 ± 2.04 μg/ml respectively. Thus the fabricated MOF has the significant antibacterial property against pathogenic bacterial strains with significantly low IC 50 values. Therefore, the compound 1 deserves to be a Bio‐MOF in the world of hybrid materials.