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Green Optimization of the First Steps for the Synthesis of a Novel Surfactant: Towards the Elimination of CMR Solvents and the Drastic Reduction of the Used Solvent Volume
Author(s) -
Giry Clément,
Bertrand David,
Cecutti Christine,
Brossard Clarisse,
Moreau Ella,
ThiébaudRoux Sophie,
VacaGarcia Carlos,
Vedrenne Emeline
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901876
Subject(s) - solvent , yield (engineering) , pulmonary surfactant , chemistry , volume (thermodynamics) , reduction (mathematics) , green chemistry , combinatorial chemistry , organic chemistry , chemical engineering , materials science , catalysis , reaction mechanism , mathematics , thermodynamics , biochemistry , physics , geometry , engineering , metallurgy
In this report, the first steps of the synthesis of a novel surfactant have been described. Each stage has been optimized to abide by the principles of green chemistry. The replacement of CMR (Carcinogenic, Mutagenic, Reprotoxic) solvents by 4‐MTHP (4‐methyltetrahydropyran) led to the improvement of the overall yield and to the drastic reduction of the total organic solvent volume used in the process.