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Rapid and Efficient Approaches for Synthesis of Some New Aryl Propionic Acid Derivatives and In–Vivo Anti‐Diabetic Screening of Selected Compounds
Author(s) -
Vekariya Mitesh B.,
Joshi Hitendra S.,
Desai Nisheeth C.,
Jadeja Krunalsinh A.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901835
Subject(s) - aryl , sonogashira coupling , chemistry , acetic acid , furan , proton nmr , coupling reaction , organic chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , catalysis , palladium , alkyl
A series of some new aryl propionic acid derivatives as 2‐(6‐(substituted phenylethynyl)‐2,3‐dihydrobenzofuran‐3‐yl)acetic acids were synthesized. The targeted molecules were prepared by using techniques such as efficient and high‐performance autoclave hydrogenation to reduce highly stable π‐electron system of furan ring and microwave‐assisted rapid Sonogashira Cross‐Coupling reaction between aryl triflate derivatives and substituted aryl acetylenes. The anti‐diabetic screening of selected compounds was performed by using alloxan‐induced diabetic model. The studies include acute and chronic toxicity, effectiveness, change in the behavioral pattern and change in glucose level of the tested animals. The compound 2‐(6‐((4‐ethylphenyl)ethynyl)‐2,3‐dihydrobenzofuran‐3‐yl)acetic acid exhibited maximum anti‐hyperglycemic properties. All the synthesized compounds were characterized by spectroscopic techniques such as 1 H‐NMR, 13 C‐NMR, IR, Mass spectrometry and single crystal XRD ( MTS‐201 ).