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Acid‐Catalyzed Four‐Component Tandem Double Cyclization: Access to Dihydroindolizino[8,7‐ b ]indoles
Author(s) -
Shirsat Prashishkumar K.,
Narasimhulu Valipenta,
Kumbhare Ravindra M.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901831
Subject(s) - tandem , chemistry , catalysis , acetylene , tryptamine , cascade reaction , alcohol , component (thermodynamics) , reaction conditions , organic chemistry , medicinal chemistry , combinatorial chemistry , materials science , biochemistry , physics , composite material , thermodynamics
The novel one pot four‐component reaction for the construction of dihydroindolizino[8,7‐ b ]indoles and their derivatives have been developed from ninhydrine, tryptamine, dimetylene acetylene dicarboxylate and aliphatic alcohol. This reaction produces to go through via Pictet‐Spengler cyclization reaction and construction of C−C and C−N bond readily achieved under transition metal free condition. Meanwhile, advantageous of tandem double cyclization are not only reducing reaction steps but also waste production.