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Metal‐Free One‐Pot Synthesis of Sulfonamides from Nitroarenes and Arylsulfonyl Chlorides in Water
Author(s) -
Zhang Kaili,
Zhang Yin,
Liu Qixing,
He Dan,
Tian Juyan,
Zhou Haifeng
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901742
Subject(s) - chemistry , sulfonamide , metal , combinatorial chemistry , organic chemistry
A metal‐free one‐pot synthesis of sulfonamides from readily available nitroarenes and arylsulfonyl chlorides promoted by diboronic acid in water has been described. Twenty‐one examples of arylsulfonamides were obtained in moderate to good yields. Notably, a disulfonamide was also prepared from dinitrobenzene by this method. In addition, this one‐pot process is applicable for gram‐scale synthesis.