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HOAc‐Assisted Synthesis of 2,3‐Disubstituted Quinolines from Arylamine and Aliphatic Aldehyde in Water
Author(s) -
Zhang JingTao,
Wang Li–Xia,
Xiang JunFeng,
Cui Jie,
Hu BenQuan,
Yang Luo,
Tang YaLin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901686
Subject(s) - quinoline , phenylacetaldehyde , aldehyde , chemistry , yield (engineering) , cleavage (geology) , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , materials science , fracture (geology) , metallurgy , composite material
Here we report that a HOAc‐assisted protocol to synthesize 2,3‐disubstituted quinolines in water, from the available starting materials arylamine and aliphatic aldehyde. The arylamine substrates showed a good universality. While the phenylacetaldehyde led to a 2,3‐disubstituted quinoline product in a very low yield, accompanied by the mono‐substituted quinoline involving C−C cleavage.