HOAc‐Assisted Synthesis of 2,3‐Disubstituted Quinolines from Arylamine and Aliphatic Aldehyde in Water | Zendy

Zhang JingTao | Zendy; Wang Li–Xia | Zendy; Xiang JunFeng | Zendy; Cui Jie | Zendy; Hu BenQuan | Zendy; Yang Luo | Zendy; Tang YaLin | Zendy

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HOAc‐Assisted Synthesis of 2,3‐Disubstituted Quinolines from Arylamine and Aliphatic Aldehyde in Water

Author(s) -

Zhang JingTao,

Wang Li–Xia,

Xiang JunFeng,

Cui Jie,

Hu BenQuan,

Yang Luo,

Tang YaLin

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201901686

Subject(s) - quinoline , phenylacetaldehyde , aldehyde , chemistry , yield (engineering) , cleavage (geology) , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , materials science , fracture (geology) , metallurgy , composite material

Here we report that a HOAc‐assisted protocol to synthesize 2,3‐disubstituted quinolines in water, from the available starting materials arylamine and aliphatic aldehyde. The arylamine substrates showed a good universality. While the phenylacetaldehyde led to a 2,3‐disubstituted quinoline product in a very low yield, accompanied by the mono‐substituted quinoline involving C−C cleavage.

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