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One‐Pot Multicomponent Synthesis of Pyrano[2,3 c]pyrazole Derivatives Using CMCSO 3 H as a Green Catalyst
Author(s) -
Ali Elham,
NaimiJamal M. Reza,
Ghahramanzadeh Ramin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901676
Subject(s) - malononitrile , pyrazole , catalysis , thermogravimetric analysis , ethyl acetoacetate , hydrazine (antidepressant) , chemistry , fourier transform infrared spectroscopy , cellulose , carboxymethyl cellulose , nuclear chemistry , organic chemistry , chemical engineering , chromatography , sodium , engineering
A promising application of sulfonated carboxymethylcellulose (SCMC) as a green heterogeneous catalyst in the synthesis of pyrano[2,3c]pyrazole derivatives has been studied here. Sulfonated carboxymethyl cellulose was synthesized through a new, green and efficient pathway. The synthesized SCMC catalyst was characterized using Fourier transform infrared (FT‐IR) spectroscopy, energy dispersive X‐ray (EDX) analysis, X‐ray diffraction (XRD) pattern, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). Its catalytic ability was then investigated in the pyranopyrazole synthesis. The SCMC as a biopolymer‐derivative solid acid catalyst indicated catalytic activity in the one‐pot multi‐component synthesis of pyrano[2,3c]pyrazole derivatives using the reaction of ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes in ethanol as a green solvent. The key features of this methodology are operational simplicity, use of a stable, recoverable, and non‐toxic catalyst, simple purification of the product by non‐chromatographic methods, high yields, environment‐friendly reaction, and economically lucrative.