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Cyclocuneatol and Cuneatannin, New Cycloartane Triterpenoid and Ellagitannin Glycoside from Euphorbia cuneata
Author(s) -
Elghamdi Amjad A.,
Abdallah Hossam M.,
Shehata Ibrahim A.,
Mohamed Gamal A.,
Shati Ali A.,
Alfaifi Mohammad Y.,
Elbehairi Serag Eldin I.,
Koshak Abdulrahman E.,
Ibrahim Sabrin R. M.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901541
Subject(s) - naringenin , euphorbiaceae , glycoside , phytochemical , euphorbia , triterpenoid , kaempferol , stereochemistry , chemistry , traditional medicine , terpene , triterpene , glucoside , flavonoid , organic chemistry , biology , biochemistry , botany , medicine , antioxidant , alternative medicine , pathology
Phytochemical investigation of the aerial parts of Euphorbia cuneata Vahl. (Euphorbiaceae) revealed new cycloartane triterpenoid, cyclocuneatol ( 2 ) and new ellagitannin glycoside, cuneatannin ( 11 ), along with nine known metabolites: β‐sitosterol ( 1 ), 3β‐hydroxycycloart‐25‐ene‐24‐one ( 3 ), cycloart‐25‐ene‐3β,24β‐diol ( 4 ), cycloart‐23 Z ‐ene‐3β,25‐diol ( 5 ), 2 R ‐naringenin ( 6 ), β‐sitosterol‐3‐ O ‐β‐D‐glucopyranoside ( 7 ), quercetin ( 8 ), kaempferol‐7‐ O ‐β‐glucoside ( 9 ), and 2 R ‐naringenin‐7‐ O ‐β‐glucoside ( 10 ). Their chemical structures were identified by detailed analyses of physical, chemical, and spectral data as well as comparison with literature. Their cytotoxic activity was assessed towards HepG2, MCF7, and HCT116 cancer cell lines by sulphorhodamine B test (SRB). It is noteworthy that 3 and 4 demonstrated the most significant activity towards HepG2, MCF7, and HCT116 cells (IC 50 2.6, 2.7, and 2.4 μM, respectively for 3 and 3.4, 4.1, and 5.3 μM, respectively for 4 ) in comparison with doxorubicin (IC 50 0.18, 0.6, and 0.2 μM, respectively).