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Synthesis and Biological Evaluation of Novel Tetrahydro‐1,2,4‐triazines Incorporating Triazene and Tetraazene Moieties
Author(s) -
Afsah Elsayed M.,
Arab Anas M.,
AbdelGalil Ebrahim
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901525
Subject(s) - triazene , hydrazone , chemistry , piperazine , piperidine , resorcinol , amine gas treating , triazine , derivative (finance) , aryl , organic chemistry , medicinal chemistry , alkyl , financial economics , economics
Diazotization of the hydrazone ( 2 ), derived from 6‐Acetyl‐2,4‐diphenyl‐tetrahydro‐1,2,4‐triazine ( 1 ), gave the corresponding 1‐chlorotriaz‐2‐enylidene derivative 3 . Coupling of 3 with resorcinol and 2‐naphthol afforded the triazenes 4 and 5 . The synthesis of tetrahydro‐1,2,4‐triazine incorporating triazene and piperidine or piperazine moieties has been achieved by coupling of 3 with the respective amine. Coupling of 3 with aromatic amines and polyhydroxy amines gave the corresponding tetraazenes. Whereas, coupling with the hydrazone 2 afforded pentaazene. In addition, the coupling of aryl diazonium salts with the hydrazone 2 was investigated.