Synthesis and Biological Evaluation of Novel Tetrahydro‐1,2,4‐triazines Incorporating Triazene and Tetraazene Moieties | Zendy

Afsah Elsayed M. | Zendy; Arab Anas M. | Zendy; AbdelGalil Ebrahim | Zendy

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Synthesis and Biological Evaluation of Novel Tetrahydro‐1,2,4‐triazines Incorporating Triazene and Tetraazene Moieties

Author(s) -

Afsah Elsayed M.,

Arab Anas M.,

AbdelGalil Ebrahim

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201901525

Subject(s) - triazene , hydrazone , chemistry , piperazine , piperidine , resorcinol , amine gas treating , triazine , derivative (finance) , aryl , organic chemistry , medicinal chemistry , alkyl , financial economics , economics

Diazotization of the hydrazone ( 2 ), derived from 6‐Acetyl‐2,4‐diphenyl‐tetrahydro‐1,2,4‐triazine ( 1 ), gave the corresponding 1‐chlorotriaz‐2‐enylidene derivative 3 . Coupling of 3 with resorcinol and 2‐naphthol afforded the triazenes 4 and 5 . The synthesis of tetrahydro‐1,2,4‐triazine incorporating triazene and piperidine or piperazine moieties has been achieved by coupling of 3 with the respective amine. Coupling of 3 with aromatic amines and polyhydroxy amines gave the corresponding tetraazenes. Whereas, coupling with the hydrazone 2 afforded pentaazene. In addition, the coupling of aryl diazonium salts with the hydrazone 2 was investigated.

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