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Syntheses of 4‐OH and 5‐OH Imidacloprids
Author(s) -
Takahashi Keisuke,
Tsurumi Tatsuya,
Inami Moe,
Li Zui,
Kusakabe Taichi,
Kikkawa Shoko,
Azumaya Isao,
Tominaga Nobuaki,
Ikenaka Yoshinori,
Arizono Koji,
Kato Keisuke
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901491
Subject(s) - neonicotinoid , chemistry , imidacloprid , sulfate , stereochemistry , medicinal chemistry , organic chemistry , pesticide , biology , agronomy
4‐OH and 5‐OH imidacloprids, important metabolites of neonicotinoid insecticides, were synthesised in 4 steps starting from S ‐methylisothiourea sulfate. The structure of 4‐OH imidacloprid was determined by X‐ray crystallographic analysis. This is the first example of the synthesis of both metabolites independently.