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Design of Phthalocyanine‐Nanoparticle Hybrids for Photodynamic Therapy Applications in Oxygen‐Deficient Tumour Environment
Author(s) -
Nwahara Nnamdi,
Managa Muthumuni,
Prinsloo Earl,
Nyokong Tebello
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901466
Subject(s) - photodynamic therapy , hypoxia (environmental) , phthalocyanine , cancer research , cancer therapy , oxygen , medicine , materials science , chemistry , cancer , nanotechnology , organic chemistry
The results show that coupling MnO2 with either AuNPs or AuNPs to phthalocyanines results in composites that significantly enhance the photodynamic therapy activity towards hypoxic MCF‐7 cancer cells. The preliminary findings from this study highlight the potential of phthalocyanines nanocomposites in reversing hypoxia‐triggered PDT resistance, and therefore, contribute to the design of hypoxia‐responsive tumour therapy systems.