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Amberlyst‐15‐catalyzed Procedure for the Synthesis of Novel 2,4‐Dihydroxybenzoyl‐1,2,3‐triazoles and Molecular Modelling Studies for Hsp‐90 Inhibition
Author(s) -
Gunduz Hande,
Kumbaraci Volkan,
Özkılıç Yılmaz,
Tüzün Nurcan Ş.,
Talinli Naciye
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901403
Subject(s) - chemistry , catalysis , cycloaddition , brønsted–lowry acid–base theory , combinatorial chemistry , organic chemistry , stereochemistry
Novel 4‐and 5‐(2,4‐dihydroxybenzoyl) triazoles were prepared from o ‐alkynoylresorcinols with by the cycloaddition reaction performed with metal free one step protocol using Bronsted acid Amberlyst‐15 as catalyst for the first time. This procedure enables the synthesis of triazoles bearing o , p ‐dihydroxybenzoyl group without the need to protection of hydroxyl groups. Products were obtained in good to excellent yields and with the moderate regioisomeric ratios. In addition, Hsp90 inhibition activities of synthesized compounds were examined by molecular modelling studies and promising results were obtained.