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Deep Eutectic Solvent Mediated Alkyne‐Carbonyl Metathesis (ACM) Reaction for the Synthesis of 2H ‐Chromene Derivatives
Author(s) -
Annes Sesuraj Babiola,
Vigneshwar Kulandaiappan,
Nivedha Kolanchinathan,
Manojveer Seetharaman,
Ramesh Subburethinam
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901350
Subject(s) - natural product , alkyne , chemistry , solvent , combinatorial chemistry , metathesis , selectivity , eutectic system , organic chemistry , catalysis , alloy , polymerization , polymer
2H ‐Chromene is an important structural motif present in many biologically active compounds, natural products and showed many other properties. Deep Eutectic Solvent (DES) an environmentally benign and alternative to the conventional organic volatile solvents has been utilized first time for the synthesis of the 2H ‐chromene derivatives in moderated to excellent yields. The DES is recycled for 5 times for the synthesis of 2H ‐chromene derivatives. Based on the stability of ring size, we justified the regio‐selectivity on the formation of cyclization product. Based on the control experiments, we ruled out the free radical mechanism and propose the ACM mechanistic path to construct chromene skeleton.