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Chloramine‐T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti‐Infective Agents
Author(s) -
Kamal Raj,
Kumar Vipan,
Kumar Ravinder,
Kumar Vikas,
Sharma Prabodh C.,
Bansal Kushal K.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901312
Subject(s) - benzothiazole , chloramine t , chloramine , chemistry , combinatorial chemistry , aryl , hybrid , stereochemistry , organic chemistry , chlorine , biology , alkyl , botany
An expedient and facile one pot synthesis of 3‐(3‐aryl‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)‐[1,2,4]triazolo[3,4‐ b ]‐1,3‐benzothiazole derivatives through in situ oxidative cyclization of corresponding N ‐heteroarylhydrazone promoted by environmentally benign chloramines‐T trihydrate at room temperature has been accomplished. Structures of all hybrids were confirmed by their spectral and elemental data. All synthesized pyrazolyltriazolobenzothiazole hybrids were also evaluated for their antibacterial and anthelmintic potential and were found to be moderate to significant anti‐infective agents.