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Cu‐Mediated C7 Acetoxylation of Indolines
Author(s) -
Gao Shanshan,
Xu Xing,
Tang Hao,
Wu JiaQiang,
Luo Junfei
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901170
Subject(s) - hydroxylation , regioselectivity , chemistry , catalysis , rhodium , ruthenium , transition metal , phenol , selectivity , stoichiometry , palladium , combinatorial chemistry , organic chemistry , medicinal chemistry , enzyme
Transition‐metal‐catalyzed acetoxylation or hydroxylation of arene C−H bonds is regarded as a valuable transformation in organic synthesis for the efficient incorporation of oxygen atoms. [1] This mode of C−H oxidation has received much attention due to the important applications of phenol derivatives in natural products, pharmaceuticals, organic synthesis, metal ligands and materials science. Early discoveries for arene C−H oxidation were generally limited due to poor selectivity, low efficiency and harsh conditions. [3] Strategie that rely coordinating directing groups have enabled the direct oxidation of a specific arene C−H bond with high regioselectivity and efficiency. This methods generally employ palladium (II) or ruthenium (II) catalysts and PhI(OAc) 2 or other stoichiometric oxidants under acidic conditions (Scheme , 1a). Methods using other transition metals, such as a rhodium (III) catalyzed ortho ‐C−H acetoxylation or hydroxylation, have also been reported.