Premium
Microwave‐Assisted Rapid Regioselective One‐Pot Synthesis of Novel 2‐Oxothiazolidine Dicarboxylate
Author(s) -
Bangade Vikas Madhukar,
Mali Prakash Rambhau,
Shirsat Prashishkumar Kishan,
Meshram Harshadas Mitaram
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901143
Subject(s) - regioselectivity , demethylation , microwave , chemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry , computer science , telecommunications , gene expression , dna methylation , gene
Abstract A regioselective synthesis of 2‐oxothiazolidine dicarboxylate (OTDC) under microwave irradiations is reported. Methoxylation, demethylation and double reductive cyclization occurs in single step by three component one pot reaction under microwave irradiations. The microwave irradiations, planar arrangement of intermediate imino(sp2)‐thio‐maleate and in situ demethylation considered as driving forces for regioselective cyclization.