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Metal–free Efficient Method for the Synthesis of N‐(2‐haloethyl)benzamides through the Ring‐opening of2‐oxazolines
Author(s) -
Guan Dan,
Luan HuoXin,
Patiguli Maimaiti,
Jiao QiuJu,
Yun QingQing,
Chen QuanSheng,
Xu ChongJun,
Nie XiaoBin,
Hu FangPeng,
Huang GuoSheng
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901109
Subject(s) - ring (chemistry) , chemistry , reaction conditions , ammonium , metal , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
An efficient, metal‐free C–H halogenated method for the synthesis of β‐halogenated carboxamides using non‐corrosive NXS (X=Cl, Br) as the halogenated source and ammonium sulfocyanide (NH 4 SCN) as the additive was proposed and accomplished. Various substituted 2‐oxazolines efficiently afforded the corresponding β‐halogenated carboxamides via a ring‐opening reaction in good yields. The characteristic features of this reaction include readily available materials, mild reaction conditions and functional groups tolerance.