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An Efficient Phosphotungstic Acid Catalysed Synthesis of 4,5‐Dioxopyrrolidines and Study of the Mechanistic Effect of the Solvent on the Reaction
Author(s) -
Basu Soumyadip,
Ghosh Tanushree,
Maity Suvendu,
Ghosh Prasanta,
Mukhopadhyay Chhanda
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201901011
Subject(s) - phosphotungstic acid , chemistry , catalysis , solvent , acetylene , reaction mechanism , organic chemistry , formaldehyde , combinatorial chemistry , alcohol , mechanism (biology) , philosophy , epistemology
An efficient protocol for the synthesis of dioxopyrrolidine scaffolds has been established using phosphotungstic acid as an effective catalyst in a multicomponent reaction of aromatic primary amines, dialkyl acetylene dicarboxylates and formaldehyde at room temperature in alcohol as a green solvent. In this methodology, the reactant solvent has an important part and is involved in the reaction mechanism to increase the versatility of the product. This protocol involves environment friendly, cost effective methodology with a comparatively simple reaction mechanism.