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Synthesis of Diamond‐Shaped Mesoporous Titania Nanobricks as pH‐Responsive Drug Delivery Vehicles for Cancer Therapy
Author(s) -
Wang Yanbing,
Wang Qi,
Zhang Chunmei
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900992
Subject(s) - biocompatibility , nanotechnology , cancer therapy , drug delivery , nanomaterials , materials science , mesoporous silica , chemistry , doxorubicin , cancer , drug carrier , mesoporous material , biophysics , biochemistry , organic chemistry , chemotherapy , medicine , biology , catalysis , surgery
Application of nanotechnology and nanomaterials in cancer therapeutics has attracted much attention in recent years. Here, we prepared diamond‐shaped mesoporous TiO 2 nanobricks (MTNs for short) via a facile and reproducible synthetic strategy. The obtained MTNs possess excellent biocompatibility, drug loading capability and pH‐responsive property through covalent conjugation to succinmidyl glutarate (PEG). These features enable the drug‐loaded PEG‐MTNs to be applied for cancer therapy. The confocal laser scanning microscopy studies show that the MTNs could be efficiently internalized by cancer cells and the loaded doxorubicin (DOX) in the MTNs could be successfully released in acidic intracellular environment. Meanwhile, the mice treated with drug‐loaded PEG‐MTNs exhibits the better tumor inhibition than those with free DOX. These data indicate the effectivity and significance of the MTNs in the cancer therapy.