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Glycerol: A Benign Solvent‐Assisted Metal‐Free One‐Pot Multi‐Component Synthesis of 4 H ‐Thiopyran and Thioamides from Easily Accessible Precursors
Author(s) -
Mitra Bijeta,
Pariyar Gyan Chandra,
Ghosh Pranab
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900982
Subject(s) - thiopyran , catalysis , chemistry , glycerol , solvent , yield (engineering) , combinatorial chemistry , component (thermodynamics) , organic chemistry , materials science , physics , thermodynamics , metallurgy
Glycerol, a green, bio‐degradable, benign solvent has been recognized to act as a highly efficient medium for the catalyst free synthesis of a vast range of highly functionalized thioamide by modified Willgerodt‐Kindler Reaction and 4 H ‐thiopyran via one‐pot multi‐component synthesis from easily accessible precursors. These protocols avoid hardnosed reaction conditions and proceed without any metal catalyst or toxic acid or solvent. In addition, these protocols have numerous advantages such as shorter reaction time, high yield and excellent functional group tolerance. Further the solvent can be recovered and reused at the end of the reaction which makes this methodology inexpensive, greener and environmentally safe protocol.