Premium
Enantioselective Syntheses of Axially Chiral Phosphonates or Phosphine Oxides via Asymmetric Suzuki Reactions with Chiral Sulfinamide Monophosphine Ligands
Author(s) -
Zhang Yaqi,
Li Yongsu,
Pan Bendu,
Xu Hao,
Liang Hao,
Jiang Xiaoding,
Liu Binyun,
Tse ManKin,
Qiu Liqin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900980
Subject(s) - enantioselective synthesis , phosphine , catalysis , axial symmetry , chemistry , combinatorial chemistry , phosphine oxide , organic chemistry , physics , quantum mechanics
A class of chiral sulfinamide monophosphine ligands Ming‐Phos were firstly employed in the asymmetric Suzuki coupling reactions. Using the in‐situ formed catalyst from PdCl 2 and ( R, S S )‐ M07 , 22 axially chiral phosphonates or phosphine oxides were successfully synthesized in 29−99% yields with up to 98% ee. This method provides a simple and efficient protocol for the synthesis of axially chiral biaryl monophosphine oxides.