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Ammonium Chloride Assisted Microwave Mediated Domino Multicomponent Reaction: An Efficient and Sustainable Synthesis of Quinazolin‐4(3 H )‐imines under Solvent Free Condition
Author(s) -
Hussen Abdulkadir Shube,
Bagchi Sourav,
Sharma Anuj
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900923
Subject(s) - domino , aniline , combinatorial chemistry , triethyl orthoformate , green chemistry , chemistry , benzonitrile , cascade reaction , organic chemistry , substrate (aquarium) , solvent , catalysis , reaction mechanism , oceanography , geology
A novel multicomponent synthesis of quinazolin‐4(3 H )‐imines starting from simple and readily available inputs is described. Herein, we report efficient and environmentally benign protocol for the synthesis of biologically significant scaffolds from readily available starting materials such as 2‐amino benzonitrile, triethyl orthoformate and mainly aniline derivatives under metal and solvent‐free conditions. Owing to its operational simplicity, step and resource economy and broad substrate scope, this robust methodology is appealing with respect to the previous research findings in this area.