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KI/K 2 S 2 O 8 ‐Mediated C‐S/C‐N Bond Formation: One‐Pot Regioselective Synthesis of 5 H ‐Thiazolo[3,2‐a]pyrimidines
Author(s) -
Yang Zan,
Liu Si,
Li An,
Liao Jiashu,
Li Lijun,
Yang Tao,
Zhou Congshan
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900793
Subject(s) - regioselectivity , chemistry , tandem , catalysis , transition metal , base (topology) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , mathematics , materials science , mathematical analysis , composite material
A new strategy for the synthesis of 5 H ‐thiazolo[3,2‐a]pyrimidines from KI/K 2 S 2 O 8 mediated C−S and C−N bond tandem cyclization reaction of enaminones with 3,4‐dihydropyrimidin‐2(1 H )‐thiones has been developed. This method features inexpensive catalyst, base free and transition‐metal free with simple procedure, affording the desired products in moderate to excellent yields.